![]() ![]() Those with diagnosed and managed type 2 diabetic conditions intending to lose weight with Contrave treatment are at higher risk of hypoglycaemic (low blood sugar) episodes. If Contrave is prescribed, a physician will closely monitor the user, assessing their heart rate and blood pressure levels periodically. Elevate blood pressure (resulting in high blood pressure / hypertension).In patients with diagnosed cardiovascular difficulties, use of Contrave may: Individuals with allergies (or hypersensitivity) to any of the active or inactive ingredients of the medicationĬontrave precautions Medical concerns and adverse effects (physical conditions and diseases) Medical concern.Individuals taking prescribed monoamine oxidase inhibitor (MAOI) medications (Contrave may not be taken at the same time as these medications and can only be considered after discontinuing MAOIs for at least 14 days) (4).Individuals already using opioid medications or opiate agonists on a chronic / long-term basis.Individuals who are already using medications containing bupropion.Individuals experiencing acute opioid medication withdrawal.Individuals in the process of discontinuing the use of various substances such as alcohol, anti-epileptic medications, barbiturates and benzodiazepines.People with diagnosed eating disorders such as bulimia and anorexia nervosa (*these may increase risk for seizures).Those with diagnosed seizure disorders, such as epilepsy or who have a history of seizures.Peoplewho have uncontrolled high blood pressure (hypertension).Should a person taking Contrave develop severe or abrupt suicidal tendencies (either thoughts, behaviours or both), major depression or worsened depression during the period of therapy, a doctor will recommend modified dosages or discontinuation of the drug. This is especially important during the initial months of therapy or following any dosage adjustments (whether increased or decreased). Should such symptoms worsen, especially if suicidal thoughts or behaviours occur, this must also be brought to the attention of the treating physician immediately.ĭoctors will also advise close friends and family of a patient prescribed Contrave to be on the lookout for any potential changes in their loved one’s mood and behaviour and proactively inform the treating doctor should any concerns arise during treatment. Any indication of a low mood (depressive symptoms), restlessness, agitation or nervousness, irritability, hostility, impulsivity, mania and hypomania, insomnia, anxiety and panic attacks must be brought to the attention of the treating medical doctor. those under 25 years of age) with major depressive or psychiatric disorders.ĭue to the severity of the warning, all patients taking Contrave will be monitored closely for the duration of their treatment. ![]() In general, many antidepressants are known to stimulate suicidal thoughts and behaviours in children, adolescents and young adults (i.e. (3)The warning indicates that physicians prescribing the medication to any patient that has had such thoughts or tendencies toward suicidal behaviours in the past take extra precaution as risk may be elevated in these individuals.īupropion is the active ingredient responsible for Contrave’s black box warning. ![]() Thus, the medication is not approved for treating major depressive or psychiatric disorders. In the case of Contrave, the black box warning stipulates that the drug may increase the occurrence of suicidal thoughts or behaviours, especially in adolescents and young adults using the medication. Significant evidence submitted to the FDA usually backs up such a warning and must be taken seriously by all medical professionals and patients using the medication. Precautions and considerations when taking ContraveĬontrave carries a black box warning, which is a strict label instruction that is issued by the FDA, warning users and medical professionals of an association with a serious adverse reaction which may occur. ![]()
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